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Optimizing polymer Lab-on-Chip platforms for ultrasonic manipulation: influence of the substrate

lab-on-chip
ultrasonic manipulation
polymeric resonators
acoustic tweezers
particle enrichment
particle separation
structure-fluid interactions
microfluidics
Itziar González, M Tijero, A Martin, V Acosta, J Berganzo, A Castillejo, M M Bouali and J L Soto
Micromachines 2015, 6(5), 574-591
http://dx.doi.org/10.3390/mi6050574

The choice of substrate material in a chip that combines ultrasound with microfluidics for handling biological and synthetic microparticles can have a profound effect on the performance of the device. This is due to the high surface-to-volume ratio that exists within such small structures and acquires particular relevance in polymer-based resonators with 3D standing waves. This paper presents three chips developed to perform particle flow-through separation by ultrasound based on a polymeric SU-8 layer containing channelization over three different substrates: Polymethyl methacrylate (PMMA); Pyrex; and a cracked PMMA composite-like structure. Through direct observations of polystyrene microbeads inside the channel, the three checked chips exhibit their potential as disposable continuous concentration devices with different spatial pressure patterns at frequencies of resonance close to 1 Mhz. Chips with Pyrex and cracked PMMA substrates show restrictions on the number of pressure nodes established in the channel associated with the inhibition of 3D modes in the solid structure. The glass-substrate chip presents some advantages associated with lower energy requirements to collect particles. According to the results, the use of polymer-based chips with rigid substrates can be advantageous for applications that require short treatment times (clinical tests handling human samples) and low-cost fabrication.

Acknowledgments

The study has been performed in the framework of two Spanish National Research Project BIO2011-30535-C04-01,02,03, “Development of a high throughput for isolation of tumor cells circulating in peripheral blood”.

RESULT
Departamento de Acústica y Evaluación No Destructiva (DAEND)
  • GAA: Grupo de Acústica ambiental
  • G CARMA: Grupo de Caracterización de materiales mediante evaluación no destructiva
  • ULAB: Ultrasonidos para el análisis de líquidos y bioingeniería
Departamento de Tecnologías de la Información y Las Comunicaciones (DTIC)
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  • GICSI: Grupo de investigación en Criptología y Seguridad de la Información
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  • PSUM: Grupo de Procesamiento de Señal en sistemas Ultrasónicos Multicanal
Departamento de Sensores y Sistemas Ultrasónicos (DSSU)
  • GSTU: Grupo de Sistemas y tecnologías ultrasónicas
  • NoySI: Grupo de Nanosensores y Sistemas Inteligentes
  • RESULT: Resonadores ultrasónicos para cavitación y micromanipulación
  • SENSAVAN: Grupo de Tecnología de Sensores Avanzados
  • QE: Electrónica Cuántica
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  • Laboratorio de Acústica
  • Laboratorio de Metrología Ultrasónica Médica (LMUM)
  • Laboratorio de Comunicaciones Cuánticas
  • Laboratory for International Collaboration in Advanced Biophotonics Imaging

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