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Ultrasonic thermometry inside tissues based on high-resolution detection of spectral shifts in overtones of scattering signals

ultrasonic detection
thermometry
tisue phantom
scattering
high resolution
spectral shifts
I. Bazán, A. Ramos, A. Ramírez, L. Leija
Physics Procedia, vol. 63, 2015, pp. 158-162
https://doi.org/10.1016/j.phpro.2015.03.026

Some research results of cooperation works in biomedical engineering, established among current national projects of Mexico and Spain, are resumed. They are related to coordinated activities of three R & D groups, with the aim to achieve high-resolution ultrasonic thermometry into tissue phantoms with internal reflectors of a non-invasive way.

Advanced spectral techniques are being used to extract thermal information in echo-signals acquired from biological phantoms with internal structures having a quasi-regular scattering distribution as, for instance, it happens in the liver tissues where a rather regular separation between scatterers has been reported. These techniques can indicate pathologies related to thermal increases due to the presence of disease. Small changes with temperature can be detected in the location of overtones of the fundamental resonance related to the separation of internal reflectors. But, this requires discarding the influence of the echoes noise on the thermal estimation results. A first evaluation of these spectral analysis techniques is performed, using echo-signals acquired from a phantom in the temperature range with medical interest, where the noise influence is shown for different levels of SNR in the echoes, using signals derived of a mathematical model for hepatic tissue echoes, where the average power, signal to noise ratio and inter-arrival time standard deviation, were taken into account. It seems that our high-resolution spectral option could be applied to detect some pathologies in tissues having regular scattering, but new advances must be performed with real tissues, in order to confirm the potential resolution of this approach.

Acknowledgments

This multinational R&D cooperation was initiated in the frame of the CYTED Project SUCoDIC (IPT-02000-2010-004), with posterior advances in the Projects CONACYT-Fomix 128572, México, and R&D Spanish National Plan Ref. DPI2011-22438. The authors acknowledge to the R&D institutions: Instituto Politécnico Nacional, ESIME Zacatenco, México, D.F.; Instituto de Tecnologías Físicas y de la Información, CSIC, Spain and Centro de Investigación y de Estudios Avanzados del IPN, CINVESTAV, México, D.F.

GSTU
Departamento de Acústica y Evaluación No Destructiva (DAEND)
  • GAA: Grupo de Acústica ambiental
  • G CARMA: Grupo de Caracterización de materiales mediante evaluación no destructiva
  • ULAB: Ultrasonidos para el análisis de líquidos y bioingeniería
Departamento de Tecnologías de la Información y Las Comunicaciones (DTIC)
  • GiCP: Grupo de investigación en Ciberseguridad y Protección de la Privacidad
  • GICSI: Grupo de investigación en Criptología y Seguridad de la Información
    • LCQE: Laboratorio de Comunicaciones Cuánticas
  • PSUM: Grupo de Procesamiento de Señal en sistemas Ultrasónicos Multicanal
Departamento de Sensores y Sistemas Ultrasónicos (DSSU)
  • GSTU: Grupo de Sistemas y tecnologías ultrasónicas
  • NoySI: Grupo de Nanosensores y Sistemas Inteligentes
  • RESULT: Resonadores ultrasónicos para cavitación y micromanipulación
  • SENSAVAN: Grupo de Tecnología de Sensores Avanzados
  • QE: Electrónica Cuántica
Laboratorios
  • Laboratorio de Acústica
  • Laboratorio de Metrología Ultrasónica Médica (LMUM)
  • Laboratorio de Comunicaciones Cuánticas
  • Laboratory for International Collaboration in Advanced Biophotonics Imaging

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