Skip to main content

Main navigation

  • About ITEFI
  • Research
  • Formación y empleo
  • OpenLab
  • Servicios científico técnicos
  • Staff Directory

TARGEAR-Targeting challenges of active ageing: innovative integrated strategies for the healing of agerelated hearing loss

  • Proyecto
  • Resultados

A FP7-PEOPLE-IAPP project leaded by Dr. Isabel Varela Nieto, from the IIBm Albelrto Sols (CSIC). Our contribution to this project was related with tinnitus, an uncomfortable symptom affecting severely the quality of life to about 1-2 % of adults. Most cases of persistent tinnitus are associated with hearing loss (HL) so that a high prevalence of tinnitus in Cochlear Implant (CI) candidates can be expected. Sound therapy may suppress tinnitus by compensating for sensory deprivation, reversing maladaptive plasticity, or enhancing lateral inhibition. There is also evidence demonstrating that an Enriched Acoustic Environment (EAE) can reduce the impact from acoustic trauma, such as hair cell deterioration and tonotopic reorganization in the auditory cortex, possibly mitigating the tinnitus-causative spontaneous rate, synchrony and cortical reorganization.

We developed EAE stimuli consisting of a sequence of gammatones, presented to the patient at a fixed rate, each one with a random frequency within the hearing frequency band, and with amplitude proportional to the HL value at such frequency. The spectrum of each gammatone provides the human auditory filter at that frequency. The EAE, as it matches the amplitude of each gammatone to the HL, is customized for each patient. Furthermore, it drives selectively each part of the damaged cochlea by the corresponding auditory filter, so that it provide the most refined stimulus for the patient. The EAE sequence of gammatones is designed for each patient, starting for his particular HL curves, using a Graphical User Interface (GUI).

Publicaciones
Año: 2015
Revistas JCR
Swept-sine noise-induced damage as a hearing loss model for preclinical assays
Sanz, L, Murillo-Cuesta, S., Cobo, P., Cediel, R., Contreras, J., Rivera, T., Varela-Nieto, I., Avendaño, C.
Frontiers in Aging Neurosciences, vol. 7, 2015, Art. 7: 1-13
http://dx.doi.org/10.3389/fnagi.2015.00007
GAA
Regresar arriba

IIBM (CSIC-UAM) - ITEFI (CSIC) - UNIFI (Italia) - Biomed (Chequia) - Affichem (Francia), MEDEL (Austria)

Datos del proyecto

TARGEAR
VII Programa Marco de Investigación y Desarrollo (UE)
PEOPLE-IAPP/3262
Investigador principal
Isabel Varela Nieto (IIBm Alberto Sols, CSIC)
Otros participantes ITEFI
Pedro Cobo Parra
Inicio: 01-01-2014 Finalización: 31-12-2017
GAA
Acoustics and Non Destructive Evaluation (DAEND)
  • Environmental Acoustics (GAA)
  • G Carma: Materials Characterization by Non Destructive Evaluation
  • ULAB, Ultrasounds for Liquid Analysis and Bioengineering
Information and Communication Technologies (TIC)
  • Cybersecurity and Privacy Protection Research Group (GiCP)
  • Research group on Cryptology and Information Security (GiCSI)
    • Quantum Communications Laboratory (LCQE)
  • Multichannel Ultrasonic Signal Processing Group (MUSP)
Sensors and Ultrasonic Systems (DSSU)
  • Ultrasonic Systems and Technologies (USTG)
  • Nanosensors and Smart Systems (NoySi)
  • Ultrasonic Resonators for cavitation and micromanipulation (RESULT)
  • Advanced Sensor Technology (SENSAVAN)
  • Quantum Electronics (QE)
Laboratorios
  • Laboratorio de Acústica
  • Laboratorio de Metrología Ultrasónica Médica (LMUM)
  • Laboratorio de Comunicaciones Cuánticas
  • Laboratory for International Collaboration in Advanced Biophotonics Imaging

Instituto de Tecnologías Físicas y de la Información Leonardo Torres Quevedo  - ITEFI
C/ Serrano, 144. 28006 - Madrid • Tel.: (+34) 91 561 88 06  Contacto  •  Intranet
EDIFICIO PARCIALMENTE ACCESIBLE POR PERSONAS CON MOVILIDAD REDUCIDA