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Effects of Low Intensity Continuous Ultrasound (LICU) on Mouse Pancreatic Tumor Explants

low-intensity continuous ultrasound
bioeffects
inflamation
tumor
interferon-y interleukins
collagen I
vasculature
Bazou, Despina; Maimon, Nir; Munn, Lance L.; González, Itziar
Applied Science 2017, 7, 1275
http://dx.doi.org/10.3390/app7121275

This paper describes the effects of low intensity continuous ultrasound (LICU) on the inflammatory response of mouse pancreatic tumor explants. While there are many reports focusing on the application of low-intensity pulsed ultrasound (LIPUS) on cell cultures and tissues, the effects of continuous oscillations on biological tissues have never been investigated. Here we present an exploratory study of the effects induced by LICU on mouse pancreatic tumor explants. We show that LICU causes significant upregulation of IFN-γ, IL-1β, and TNF-α on tumor explants. No detectable effects were observed on tumor vasculature or collagen I deposition, while thermal and mechanical effects were not apparent. Tumor explants responded as a single unit to acoustic waves, with spatial pressure variations smaller than their size.

Acknowledgments

The authors would like to acknowledge funding from the National Institutes of Health (R01HL106584) and i-LINK (I-LINK0979). We thank Anna Khachatryan for her help with the ELISA assays.

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