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Mechanical characterization of biological fluids and tissues at cellular resolution range

  • Proyecto
  • Otros

There is an actual interest within the global scientific community in the development of non-invasive imaging systems at cellular resolution level. Such devices are used to analyse cell characteristics, relations among cells in tissues and also quantify cell metrics as elasticity or concentration. Diagnostic and treatment studies both in vivo and in vitro and tissue engeneering reasearch will take benefit of such a tool.

Mechanical properties of biological fluids and tissues can be interrogated through the analysis of tissue reflectivity, absorption spectrum and texture parameters. These are basic characteristics for cellular interaction processes and disease development.The present project aims to investigate biological formations constituted by eukaryotic cells through the development of an ultrasound scanning probe based on a wideband (15-70MHz) focalized transducer. The development of such analysis techniques would be applied as diagnostic tools and also as a quality control technique for tissue engineering science.

 

Objectives

The general objective of this proposal is to increase the knowledge about the potential of quantitative ultrasound techniques to characterize biological fluids and tissues at the celular resolution range. This will be achieved through the following specific objectives:

  1. Development of a high frequency ultrasound portable probe based on a 2D scanning micromechanism.
  2. Characterization of cell formations using the probe. (Cell monolayers and dilute cell suspensions).

 

Image of blood vessel phantom (1 mm diameter) using the ultrasound imaging system with 50MHz probe.
Congresos y reuniones, conferencias
2023
Focalización de apertura sintética en sistemas monotransductor para aumentar la profundidad de foco en imagenes ultrasónicas de alta frecuencia
Presentación oral

Óscar Martínez-Graullera, Luis Elvira Segura, Carmén Durán Gómez, Montserrat Parrilla Romero, Alberto Ibáñez Rodríguez, Carla de León Morán, Ruslan Shaporin 
TECNIACÚSTICA 2023
Del 18 al 20 de octubre de 2023, Cuenca, España.


Puede descargar la presentación haciendo clic aquí (9.63 MB)
ULAB PSUM
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Datos del proyecto

UCRAN2017
Programa CSIC de cooperación científica con Ucrania
UCRAN2017
Investigador principal
Luis Elvira Segura
Otros participantes ITEFI
M. Iciar González Gómez
Alberto Ibáñez Rodríguez
Oscar Martínez Graullera
Montserrat Parrilla Romero
Inicio: 12-12-2022 Finalización: 11-12-2024
RESULT ULAB PSUM
Acoustics and Non Destructive Evaluation (DAEND)
  • Environmental Acoustics (GAA)
  • G Carma: Materials Characterization by Non Destructive Evaluation
  • ULAB, Ultrasounds for Liquid Analysis and Bioengineering
Information and Communication Technologies (TIC)
  • Cybersecurity and Privacy Protection Research Group (GiCP)
  • Research group on Cryptology and Information Security (GiCSI)
    • Quantum Communications Laboratory (LCQE)
  • Multichannel Ultrasonic Signal Processing Group (MUSP)
Sensors and Ultrasonic Systems (DSSU)
  • Ultrasonic Systems and Technologies (USTG)
  • Nanosensors and Smart Systems (NoySi)
  • Ultrasonic Resonators for cavitation and micromanipulation (RESULT)
  • Advanced Sensor Technology (SENSAVAN)
  • Quantum Electronics (QE)
Laboratorios
  • Laboratorio de Acústica
  • Laboratorio de Metrología Ultrasónica Médica (LMUM)
  • Laboratorio de Comunicaciones Cuánticas
  • Laboratory for International Collaboration in Advanced Biophotonics Imaging

Instituto de Tecnologías Físicas y de la Información Leonardo Torres Quevedo  - ITEFI
C/ Serrano, 144. 28006 - Madrid • Tel.: (+34) 91 561 88 06  Contacto  •  Intranet
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