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Graphene-doped tin oxide nanofibers and nanoribbons as gas sensors to detect biomarkers of different diseases through the breath

electronic nose
nanosensors
nanofibers
nanoribbons
nanostructures
gas sensors
biomarkers
graphene
respiratory diseases
digestive diseases
chronic diseases
volatile organic compounds - VOC
breath
asthma
COPD
diabetes
pneumonia
cystic fibrosis
staphylococcus aureus
Carlos Sánchez-Vicente, José Pedro Santos, Jesús Lozano, Isabel Sayago, José Luis Sanjurjo, Alfredo Azabal, Santiago Ruiz-Valdepeñas.
Sensors (Switzerland), 2020, 20(24), pp. 1–12, 7223
https://doi.org/10.3390/s20247223

This work presents the development of tin oxide nanofibers (NFs) and nanoribbons (NRs) sensors with graphene as a dopant for the detection of volatile organic compounds (VOCs) corresponding to different chronic diseases (asthma, chronic obstructive pulmonary disease, cystic fibrosis or diabetes). This research aims to determine the ability of these sensors to differentiate between gas samples corresponding to healthy people and patients with a disease. The nanostructures were grown by electrospinning and deposited on silicon substrates with micro-heaters integrated. The morphology of NFs and NRs was characterized by Scanning Electron Microscopy (SEM). A gas line was assembled and programmed to measure a wide range of gases (ethanol, acetone, NO and CO) at different concentrations simulating human breath conditions. Measurements were made in the presence and absence of humidity to evaluate its effect. The sensors were able to differentiate between the concentrations corresponding to a healthy person and a patient with one of the selected diseases. These were sensitive to biomarkers such as acetone and ethanol at low operating temperatures (with responses above 35%). Furthermore, CO and NO response was at high temperatures (above 5%). The sensors had a rapid response, with times of 50 s and recovery periods of about 10 min.

Keywords: electronic nose; nanosensor; nanofibers; nanoribbons; nanostructures; gas sensors; biomarkers; graphene; respiratory diseases; digestive diseases; chronic diseases; volatile organic compounds; VOC; breath; asthma; COPD; diabetes; pneumonia; cystic fibrosis; Staphylococcus aureus

Funding

This research was funded by Department of Education and Research of the Madrid Autonomous Community (Spain) grant number IND2017/TIC7714.

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